A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms
Principal Investigator: Kah Poh Loh
Short Title: UCCS21043 / Go-EXCAP II / Loh
Scope: Local
Description: This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.
Eligibility Information
Age Group: Adult, Older Adult
Eligibility Reqs:
Inclusion Criteria:
- Age ≥60 years (conventional definition of older age in clinical trials of MN)
- Have a diagnosis of MN
- Planned for or receiving outpatient cancer-directed treatments (patients receiving consolidative or maintenance outpatient therapies after induction chemotherapy are allowed to enroll)
- English speaking
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-3
- No medical contraindications for exercise per oncologist
- Able to walk 4 meters as part of Short Physical Performance Battery measured walk (with or without assistive device)
- Able to provide informed consent
Exclusion Criteria:
- Physical, psychological, or social impairments that would interfere with patient's ability to participate in the study or participate in the intervention, as determined by the PI or the treating team
Contact Information
Additional Information
OnCore Trial ID: ONC103762